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yoda1  (MedChemExpress)
96
MedChemExpress yoda1
Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist <t>Yoda1</t> and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).
Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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piezo1 specific agonist yoda1  (MedChemExpress)
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MedChemExpress piezo1 specific agonist yoda1
Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist <t>Yoda1</t> and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).
Piezo1 Specific Agonist Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy 19608 yoda1 medchemexpress  (MedChemExpress)
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MedChemExpress hy 19608 yoda1 medchemexpress
Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist <t>Yoda1</t> and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).
Hy 19608 Yoda1 Medchemexpress, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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piezo1 agonist yoda1  (MedChemExpress)
96
MedChemExpress piezo1 agonist yoda1
Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist <t>Yoda1</t> and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).
Piezo1 Agonist Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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molecules yoda1  (MedChemExpress)
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MedChemExpress molecules yoda1
Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist <t>Yoda1</t> and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).
Molecules Yoda1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist Yoda1 and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).

Journal: Materials Today Bio

Article Title: Age-mimicking hydrogel stiffness recapitulates the mechanical niche of the hippocampus to regulate neural stem cell senescence

doi: 10.1016/j.mtbio.2026.102985

Figure Lengend Snippet: Intervention of Piezo1 activity altered NSC proliferation on hydrogels mimicking different niche stiffness . (a) The mRNA expression level of Piezo1 in FACS-Young, FACS-Old, Hydrogel-Soft, and Hydrogel-Stiff NSCs groups (n = 3). ( b ) The strategy for treating 8-week-old adult NSCs cultured on soft and stiff hydrogels with the Piezo1 agonist Yoda1 and performing EdU labeling assays. ( c ) EdU detection in adult NSCs on soft and stiff hydrogels treated with 2 μm Yoda1 for 48 h, compared to DMSO mock. Scale bar, 50 μm. ( d ) Quantification of EdU + proliferating NSCs as in ( c ) (n = 3). ( e ) Piezo1 protein immunostaining in the scramble control and Piezo1 knockdown NSCs. Scale bars, 100 μm and 50 μm as indicated. ( f ) qPCR analysis of Piezo1 mRNA expression levels in the scramble control and Piezo1 knockdown NSCs (n = 3). ( g ) EdU detection in scramble control and Piezo1 knockdown NSCs cultured on stiff hydrogels. Scale bar, 100 μm. ( h ) Quantification of EdU + NSCs as in ( g ) (n = 3). ( i-l ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the DMSO and 2 μM Yoda1 treatment groups, n = 3. ( m-p ) qPCR analysis of Cdk4, Haus1, Col6a4, and Col6a6 genes in the Scramble and Piezo1 knockdown groups, n = 3. Statistical significance was determined using unpaired Student’s t tests (a, f, h-p). Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparison tests (d). Data are presented as mean ± SEM (a) and mean ± SD(d, f, h, i-p) (∗p < 0.05, ∗∗p < 0.01).

Article Snippet: After 24 h of culture, the medium was replaced with medium containing 2 μM Yoda1 (MCE, HY-18723) to treat the cells for 48 h. Subsequently, 15 μM EdU was added to the medium for 4 h to label proliferating cells.

Techniques: Activity Assay, Expressing, Cell Culture, Labeling, Immunostaining, Control, Knockdown, Comparison